Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

Article Title: Development and Optimization of a Novel Automated Loop Method for Production of [ 11 C]Nicotine

doi: 10.1016/j.apradiso.2018.05.030

Figure Lengend Snippet: Analytical RP-HPLC chromatograms of (a) 11C-Nicotine (b) Nicotine standard (c) (+) Nornicotine Precursor and (d) 11CH3I.

Article Snippet: The [ 11 C]Nicotine production process was developed and optimized using an automated MeI Plus loop system (from Synthra GmbH) equipped with a semi-preparative HPLC system, consisting of a quaternary pump and variable wavelength UV (254nm) and radioisotope detectors.

Techniques:

Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

Article Title: Development and Optimization of a Novel Automated Loop Method for Production of [ 11 C]Nicotine

doi: 10.1016/j.apradiso.2018.05.030

Figure Lengend Snippet: Summary of Analytical Testing Results of [ 11 C]Nicotine

Article Snippet: The [ 11 C]Nicotine production process was developed and optimized using an automated MeI Plus loop system (from Synthra GmbH) equipped with a semi-preparative HPLC system, consisting of a quaternary pump and variable wavelength UV (254nm) and radioisotope detectors.

Techniques: Activity Assay, Sterility

Journal: International Journal of Molecular Sciences

Article Title: Preclinical Evaluation of [ 18 F]FACH in Healthy Mice and Piglets: An 18 F-Labeled Ligand for Imaging of Monocarboxylate Transporters with PET

doi: 10.3390/ijms22041645

Figure Lengend Snippet: Metabolism and renal excretion of [ 18 F]FACH in mice and piglets. ( A ) Representative radio-HPLC chromatograms of indicated tissues extracts (a.u.-arbitrary unit), red boxes indicating the neutral and deprotonated form (parent) of [ 18 F]FACH . ( B ) Parent radiotracer fraction over time in plasma of piglets in control ( n = 3) and α -CCA-Na pre-treated group ( n = 3). ( C ) Plasma metabolite plot for [ 18 F]FACH in a representative piglet, where the ordinate intercept corresponds to the whole body fractional rate constant for [ 18 F]FACH ( k 0 , min −1 ), and the inverse of the linear regression slope indicates the fractional rate constant for elimination of the pooled plasma radio-metabolites ( k −1 , min −1 ) . ( D ) Renally excreted 18 F-activity as percentage of injected dose (%ID) after 60 min in piglets (control: n = 1, α -CCA-Na pre: n = 2) and mice (vehicle: n = 10, α -CCA-Na pre: n = 5; mean ± SD).

Article Snippet: Radio-metabolites were analyzed by analytical and semi-preparative HPLC on a JASCO LC-2000 system (JASCO Labor- und Datentechnik, Gross-Umstadt, Germany), consisting of a PU-2080 Plus pump, AS-2055 Plus auto injector (100 μL sample loop) or a manual injection valve with a 5 mL sample loop, and a UV-2070 Plus detector coupled with a gamma radioactivity HPLC detector (Gabi Star, Raytest Isotopenmessgeräte GmbH, Straubenhardt, Germany).

Techniques: Clinical Proteomics, Control, Activity Assay, Injection